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AQP2 Antibody

CAT: 0223-7621-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7621-01Size:0.02 mg
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Background
Aquaporins are membrane proteins that serve in the transfer of water and small solutes across cellular membranes. One such aquaporin, aquaporin-2 (AQP2) is located in the kidney collecting tubule and plays a critical role in water reabsorbtion (1) . AQP2 is mainly localized in intracellular vesicles but upon stimulation with anti-diuretic hormone (ADH), AQP2 is translocated to the apical plasma membrane by exocytic fusion of AQP2-bearing vesicles (2) . Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus (3) .
NCBI Gene ID
359
Swiss Prot
P41181
Accession Number
NP_000477
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
AQP2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Sheep: (100%), Bovine: (95%)
Buffer
AQP2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
AQP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
AQP2 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with other members of the aquaporin protein family.
Symbol
AQP2
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Aquaporin 2 (collecting duct)
NCBI Organism
Homo sapiens
Background Reference 01
Denker BM, Smith BL, Kuhada FP, et al. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J. Biol. Chem. 1988; 263:15634-42.
Background Reference 02
Barile M, Pisitkun T, Yu MJ, et al. Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Mol. Cell Proteomics 2005; 4:1095-106.
Background Reference 03
Bockenhauer D and Bichet DG. Inherited secondary nephrogenic diabetes insipidus: concentrating on humans. Am. J. Physiol. Renal Physiol. 2013; 304:F1037-42.
Other Product Names
AQP2 Antibody: AQP-CD, WCH-CD, Aquaporin-2, ADH water channel, AQP-2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4502179
Physical Properties
Liquid

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