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RPSA Antibody

CAT: 0223-7605-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7605-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1) . Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2) . RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3) .
NCBI Gene ID
3921
Swiss Prot
P08865
Accession Number
NP_002286
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
RPSA antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1223 - Caco-2 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (100%), Rat: (100%), Sheep: (100%)
Buffer
RPSA antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RPSA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
RPSA antibody is human, mouse and rat reactive.
Symbol
RPSA
NCBI Official Name
Ribosomal protein SA
NCBI Organism
Homo sapiens
Background Reference 01
Jackers P, Minoletti F, Belotti D, et al. Isolation from a multigene family of the active human gene of the metastasis-associated 67kDa laminin binding protein 37LRP/p40 at chromosome 3p21.3. Oncogene 1996; 13:495-503.
Background Reference 02
Savino W and Silva-Barbosa SD. Laminin/VLA-6 interactions and T cell function. Braz. J. Med. Biol. Res. 1996; 29:1209-20.
Background Reference 03
Kumazoe M, Sugihara K, Tsukamoto S, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J. Clin. Invest. 2013; 123:787-99.
Other Product Names
RPSA Antibody: SA, LBP, LRP, p40, 67LR, ICAS, lamR, 37LRP, LAMBR, LAMR1, LRP/LR, LBP/p40, NEM/1CHD4, 40S ribosomal protein SA, 37 kDa laminin receptor precursor
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
9845502
Physical Properties
Liquid

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