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IL-22 Antibody

CAT: 0223-7593-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7593-01Size:0.02 mg
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Background
Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1) . Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2) . IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3) .
NCBI Gene ID
50616
Swiss Prot
Q9GZX6
Accession Number
NP_065386
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
IL-22 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
IL-22 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-22 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IL-22 antibody is human, mouse, and rat reactive. Multiple isoforms of IL-22 are known to exist.
Symbol
IL22
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Interleukin 22
NCBI Organism
Homo sapiens
Background Reference 01
Xie MH, Aggarwal S, Ho WH, et al. Interleukin (IL) -22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 2000; 275:31335-9.
Background Reference 02
Wolk K, Kunz S, Witte E, et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21:241-54.
Background Reference 03
Wolk K, Witte E, Wallace E, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36:1309-23.
Other Product Names
IL-22 Antibody: TIFa, IL-21, IL-22, ILTIF, IL-TIF, IL-D110, zcyto18, TIFIL-23, ZCYTO18, UNQ3099/PRO10096, Interleukin-22, Cytokine Zcyto18
Tested Applications
ELISA, WB, ICC, IF
Protein ID
10092625
Physical Properties
Liquid

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