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IL-36RN Antibody

CAT: 0223-7511-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7511-01Size:0.02 mg
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Background
IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2) . The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3) . Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4) .
NCBI Gene ID
26525
Swiss Prot
Q9UBH0
Accession Number
NP_775262
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
IL-36RN antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-36RN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Observed Molecular Weight: 24 kDa
Fragment
IgG
Specificity
IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist
Symbol
IL36RN
NCBI Official Name
Interleukin 36 receptor antagonist
NCBI Organism
Homo sapiens
Background Reference 01
Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75.
Background Reference 02
Debets R, Timans JC, Homey B, et al. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 2001; 167:1440-6.
Background Reference 03
Blumberg H, Dinh H, Trueblood ES, et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J. Exp. Med. 2007; 204:2603-14.
Background Reference 04
Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.
Other Product Names
IL-36RN Antibody: FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1 (DELTA), UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
27894310
Physical Properties
Liquid

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