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IL-36A Antibody

CAT: 0223-7505-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7505-01Size:0.02 mg
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Background
IL-36A is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36A is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2) . Like the related proteins IL-36B and IL-36G, IL-36A requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3) . The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (4) .
NCBI Gene ID
27179
Swiss Prot
Q9UHA7
Accession Number
NP_055255
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
IL-36A antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1219 - MCF7 Cell Lysate
Concentration
1 mg/mL
Buffer
IL-36A antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-36A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IL-36A antibody is human specific. IL-36A antibody will not cross-react with IL-36B or IL-36G.
Symbol
IL36A
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Interleukin 36, alpha
NCBI Organism
Homo sapiens
Background Reference 01
Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75.
Background Reference 02
Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL) -1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.
Background Reference 03
Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.
Background Reference 04
Vigne S, Palmer G, Martin P, et al. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. Blood 2012; 120:3478-87.
Other Product Names
IL-36A Antibody: FIL1, FIL1E, IL1F6, IL-1F6, IL1 (EPSILON), FIL1 (EPSILON), IL1E, Interleukin-36 alpha, FIL1 epsilon, IL-1 epsilon
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7657092
Physical Properties
Liquid

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