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IL-1F10 Antibody

CAT: 0223-7503-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7503-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1) . IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2) . IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3) . IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4) .
NCBI Gene ID
84639
Swiss Prot
Q8WWZ1
Accession Number
NP_775184
Host
Rabbit
Reactivity
Human
Immunogen
7503
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 1) : Anti- IL-1F10 antibodies (7503) detected human IL-1F10 recombinant protein at different concentrations. Recombinant Protein Test7503
Field of Research
Immunology
Purification
IL-1F10 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse (100%) and Rat (88%) .
Buffer
IL-1F10 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-1F10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IL-1F10 antibody is human, mouse and rat reactive. Two isoforms of IL-1F10 exist.
Isoform
Human IL-1F10 has 2 isoforms, including isoform 1 (152aa, 17kD) and isoform 2 (152aa, 17kD) . Mouse IL-1F10 has one isoform (152aa, 17kD) and Rat IL-1F10 also has one isoform (152aa, 17kD) . 7503 can detect human, mouse and rat.
Symbol
IL1F10
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Interleukin 1 family, member 10 (theta)
NCBI Organism
Homo sapiens
Background Reference 01
Towne et al. J. Biol. Chem. 2004; 279:13677-88.
Background Reference 02
Lin et al. J. Biol. Chem. 2001; 276: 20597-602.
Background Reference 03
Bensen et al. J. Interferon Cytokine Res. 2001; 21:899-904.
Background Reference 04
Cruz-Robles et al. Immunol. Invest. 2009; 38:231-9.
Other Product Names
IL-1F10 Antibody: IL-38, FKSG75, IL1HY2, IL-1HY2, IL1-theta, FIL1-theta, FIL1T, IL38, UNQ6119/PRO20041, Interleukin-1 family member 10, Family of interleukin 1-theta, IL-1F10
Tested Applications
ELISA, WB, IHC-P
Protein ID
27894307
Physical Properties
Liquid

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