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IL-1RL2 Antibody

CAT: 0223-7501-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7501-01Size:0.02 mg
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Background
IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity (1) . Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway (2) . IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response (3) .
NCBI Gene ID
8808
Swiss Prot
Q9HB29
Accession Number
NP_003845
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
IL-1RL2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Concentration
1 mg/mL
Buffer
IL-1RL2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-1RL2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
IL-1RL2 antibody is human, mouse and rat reactive. At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is predicted to not cross-react with IL-1R or IL-1RL1.
Symbol
IL1RL2
Positive Control 2
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
Interleukin 1 receptor-like 2
NCBI Organism
Homo sapiens
Background Reference 01
Lovenberg TW, Crowe PD, Liu C, et al. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1 1R-rp2) . J. Neuroimmunol. 1996; 70:113-22.
Background Reference 02
Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL) -1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.
Background Reference 03
Van de Veerdonk FL, Stoeckman AK, Wu G, et al. IL-38 beinds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist. Proc. Natl. Acad. Sci. USA 2012; 109:3001-5.
Other Product Names
IL-1RL2 Antibody: IL-36R, IL1RRP2, IL-1Rrp2, IL1R-rp2, Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
28416902
Physical Properties
Liquid

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