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IL-37 Antibody

CAT: 0223-7499-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7499-01Size:0.02 mg
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Background
Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1) . It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp) . IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1) . IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3) .
NCBI Gene ID
27178
Swiss Prot
Q9NZH6
Accession Number
NP_055254
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
IL-37 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-37 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.
Symbol
IL37
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Interleukin 37
NCBI Organism
Homo sapiens
Background Reference 01
Boraschi D, Lucchesi D, Hainzl S, et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur. Cytokine Netw. 2011; 22:127-47.
Background Reference 02
Nold MF, Nold-Petry CA, Zepp JA, et al. Interleukin 37 is a fundamental inhibitor of innate immunity. Nat. Immunol. 2010; 11:1014-22.
Background Reference 03
Sakai N, Van Sweringen HL, Belizaire RM, et al. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J. Gastroenterol. Hepatol. 2012; 27:1609-16.
Other Product Names
IL-37 Antibody : FIL1, FIL1Z, IL-1H, IL-37, IL1F7, IL1H4, IL-1F7, IL-1H4, IL1RP1, IL-1RP1, FIL1 (ZETA), Interleukin-37, FIL1 zeta
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
20127524
Physical Properties
Liquid

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