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IL-12A Antibody

CAT: 0223-7497-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7497-01Size:0.02 mg
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Background
IL-12A is subunit of the cytokine IL-12 which acts on T- and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 35-kD subunit and a 40-kD subunit that is a member of the cytokine receptor family (1) . IL-12 is required for the T-cell-independent induction of interferon (IFN) -gamma, and is important for the differentiation of both Th1 and Th2 cells (1,2) . The responses of lymphocytes to IL-12 are mediated by the activator of transcription protein STAT4 (2) . Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity (3) .
NCBI Gene ID
3592
Swiss Prot
P29459
Accession Number
NP_000873
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Innate Immunity
Purification
IL-12A antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Llama: (94%), Goat: (89%), Pig: (89%), Sheep: (89%), Horse: (83%), Bovine: (83%)
Buffer
IL-12A antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-12A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IL-12A antibody is human specific. IL-12A antibody will not cross-react with IL-12B.
Symbol
IL 12A
NCBI Official Name
Interleukin 12A
NCBI Organism
Homo sapiens
Background Reference 01
Gee K, Guzzo C, Che Mat NF, et al. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm. Allergy Drug Targets 2009; 8:40-52.
Background Reference 02
Sinigaglia F, D'Ambrosio D, Panina-Bordignon P, et al. Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function. Immunol. Rev. 1999; 170:65-72.
Background Reference 03
Bogdan C, Rollinghoff M, and Diefenbach A. The role of nitric oxide in innate immunity. Immunol. Rev. 2000; 173:17-26.
Other Product Names
Interleukin 12 alpha, p35, natural killer cell stimulatory factor 1, NKSF1, cytotoxic lymphocyte maturation factor 1, CLMF, NF cell stimulatory factor chain 1, NFSK
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
24430219
Physical Properties
Liquid

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