IL-28B Antibody

• Background:

  Interleukin 28 (IL-28B), also known as interferon lambda 3, is cytokine distantly related to type I interferons and the IL-10 family (1) . The IL-28B gene and the closely related cytokine genes IL-28A and IL-29 form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection and can induce anti-viral activity (2,3) . All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor-beta (IL10RB) and interleukin 28 receptor- alpha (IL28RA) (1) .

• NCBI Gene ID:

  282617

• Swiss Prot:

  Q8IZI9

• Accession Number:

  NP_742151

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  IL-28B Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  IL-28B Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IL-28B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  IL-28B antibody is human specific. IL-28B antibody may cross-react with IL-28A and IL-29.

• Symbol:

  IFNL3

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Interferon, lambda 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sheppard P, Kindsvogel W, Xu W, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat. Immunol. 2003; 4:63-8.

• Background Reference 02:

  Osterlund PI, Pietila TE, Veckman V, et al. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J. Immunol. 2007; 179:3434-42.

• Background Reference 03:

  Meager A, Visvalingam K, Dilger P, et al. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine 2005; 31:109-18.

• Other Product Names:

  IL-28B Antibody : IL28B, IL28C, IL-28B, IL28B, ZCYTO22, Interferon lambda-3, Cytokine Zcyto22, IFN-lambda-3

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  28144901

• Physical Properties:

  Liquid