TFPI Antibody

• Background:

  TFPI Antibody: Tissue factor pathway inhibitor (TFPI), also known as lipoprotein-associated coagulation inhibitor, is a protease inhibitor that regulates the tissue factor (TF) -dependent pathway of blood coagulation (1) . TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop (1) .

• NCBI Gene ID:

  7035

• Swiss Prot:

  P10646

• Accession Number:

  NP_006278

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  TFPI Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1468 - Rat Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Rabbit: (92%)

• Buffer:

  TFPI Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TFPI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TFPI antibody is human, mouse and rat reactive. At least two isoforms of TFPI are known to exist; this antibody will detect both isoforms.

• Symbol:

  TFPI

• NCBI Official Name:

  Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Broze GJ Jr and Girard TJ. Tissue factor pathway inhibitor: structure-function. Front. Biosci. 17:262-80.

• Other Product Names:

  TFPI Antibody: EPI, TFI, LACI, TFPI1, Tissue factor pathway inhibitor, Extrinsic pathway inhibitor, TFPI

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  5454114

• Physical Properties:

  Liquid