CD59 Antibody

• Background:

  CD59 Antibody: The complement regulatory protein CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and ultimately cerebral infarction.

• NCBI Gene ID:

  966

• Swiss Prot:

  P13987

• Accession Number:

  NP_000602

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  CD59 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1406 - Mouse Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (86%)

• Buffer:

  CD59 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CD59 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  14 kDa

• Fragment:

  IgG

• Symbol:

  CD59

• NCBI Official Name:

  CD59 molecule, complement regulatory protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Venneker GT and Asghar SS. CD59: a molecule involved in antigen presentation as well as downregulation of membrane attack complex. Exp. Clin. Immunogenet. 1992; 9:33-47.

• Background Reference 02:

  Kimberly FC, Sivasankar B, and Paul Morgan B. Alternative roles for CD59. Mol. Immunol. 2007; 44:73-81.

• Background Reference 03:

  Ninomiya H and Sims PJ. The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the “b” domain of C9. J. Biol. Chem. 1992; 267:13675-80.

• Background Reference 04:

  Deckert M, Ticchioni M, Mari B, et al. The glycosylphosphatidylinositol-anchored CD59 protein stimulates both T cell receptor zeta/ZAP-70-dependent and –independent signaling pathways in T cells. Eur. J. Immunol. 1995; 25:1815-22

• Other Product Names:

  CD59 Antibody: 1F5, EJ16, EJ30, EL32, G344, MIN1, MIN2, MIN3, MIRL, HRF20, MACIF, MEM43, MIC11, MSK21, 16.3A5, HRF-20, MAC-IP, p18-20, CD59 glycoprotein, 1F5 antigen

• Tested Applications:

  ELISA, WB

• Protein ID:

  10835165

• Physical Properties:

  Liquid