IL-15 Antibody

• Background:

  IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.

• NCBI Gene ID:

  3600

• Swiss Prot:

  P40933

• Accession Number:

  NP_000576

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  IL-15 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1466 - Rat Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Guinea pig: (100%), Sheep: (92%), Rabbit: (92%), Pig: (92%), Bovine: (92%)

• Buffer:

  IL-15 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  IL-15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  18 kDa

• Fragment:

  IgG

• Specificity:

  At least two isoforms of IL-15 are known to exist.

• Symbol:

  IL15

• NCBI Official Name:

  Interleukin 15

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.

• Background Reference 02:

  Ku CC, Murakami M, Sakamoto A, et al. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000; 288:675-8.

• Background Reference 03:

  Waldmann T, Tagaya Y, and Bamford R. Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 1998; 16:205-26.

• Background Reference 04:

  Masuda A, Matsuguchi T, Yamaki K, et al. Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediate Bcl-xL expression. J. Biol. Chem. 2001; 276:26107-13.

• Other Product Names:

  IL-15 Antibody: IL-15, Interleukin-15, IL-15

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  10835153

• Physical Properties:

  Liquid