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BCL3 Antibody

CAT: 0223-7183-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7183-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ -B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ -B proteins. The expression of this gene can be induced by NF-κ -B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ -B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.
NCBI Gene ID
602
Swiss Prot
P20749
Accession Number
NP_005169
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
BCL3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BCL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 50 kDa
Fragment
IgG
Symbol
BCL3
NCBI Official Name
B-cell CLL/lymphoma 3
NCBI Organism
Homo sapiens
Background Reference 01
Ohno H, Takimoto G, and McKeithan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 1990; 60:991-7.
Background Reference 02
Wulczyn FG, Naumann M, and Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature 1992; 358:597-9.
Background Reference 03
Ibrahim HA, Amen F, Reid AG, et al. BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma. Eur. J. Haematol. 2011; 87:480-5.
Background Reference 04
Ge B, Li O, Wilder P, et al. NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer. J. Immunol. 2003; 171:4210-8.
Other Product Names
BCL3 Antibody: BCL4, D19S37, BCL4, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL-3
Tested Applications
ELISA, WB
Protein ID
164664508
Physical Properties
Liquid

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