BCL3 Antibody

• Background:

  BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ -B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ -B proteins. The expression of this gene can be induced by NF-κ -B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ -B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.

• NCBI Gene ID:

  602

• Swiss Prot:

  P20749

• Accession Number:

  NP_005169

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  BCL3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  BCL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  Predicted: 50 kDa

• Fragment:

  IgG

• Symbol:

  BCL3

• NCBI Official Name:

  B-cell CLL/lymphoma 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ohno H, Takimoto G, and McKeithan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 1990; 60:991-7.

• Background Reference 02:

  Wulczyn FG, Naumann M, and Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature 1992; 358:597-9.

• Background Reference 03:

  Ibrahim HA, Amen F, Reid AG, et al. BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma. Eur. J. Haematol. 2011; 87:480-5.

• Background Reference 04:

  Ge B, Li O, Wilder P, et al. NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer. J. Immunol. 2003; 171:4210-8.

• Other Product Names:

  BCL3 Antibody: BCL4, D19S37, BCL4, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL-3

• Tested Applications:

  ELISA, WB

• Protein ID:

  164664508

• Physical Properties:

  Liquid