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CHCHD7 Antibody

CAT: 0223-7143-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7143-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CHCHD7 Antibody: CHCHD7 is a newly identified member of a multifamily of proteins containing a conserved (coiled coil 1) - (helix 1) - (coiled coil 2) - (helix 2) domain. Northern blot analysis revealed that the gene is ubiquitously expressed. Its biological function is unknown and the gene has hitherto not been associated with neoplasia. CHCHD7 and PLAG1 are located head-to-head about 500 bp apart in 8q12. A chromosomal aberration involving CHCHD7 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland.
NCBI Gene ID
79145
Swiss Prot
Q9BUK0
Accession Number
NP_077276
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
CHCHD7 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (71%)
Buffer
CHCHD7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CHCHD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 11 kDa
Fragment
IgG
Specificity
Three alternatively spliced transcript variants have been observed. CHCHD7 is predicted to not cross-react to other members of the CHCHD family.
Symbol
CHCHD7
NCBI Official Name
Coiled-coil-helix-coiled-coil-helix domain containing 7
NCBI Organism
Homo sapiens
Background Reference 01
Asp J, Persson F, Kost-Alimova M, et al. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer 2006; 45:820-8.
Background Reference 02
Nishimura S, Watanabe T, Mizoshita K, et al. Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattle. BMC Genet. 2012; 13:40.
Background Reference 03
Matsuyama A, Hisaoka M, and Hashimoto H. PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study. Virchows Arch. 2011; 459:539-45.
Other Product Names
CHCHD7 Antibody: COX23, Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
Tested Applications
ELISA, WB
Protein ID
64464338
Physical Properties
Liquid

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