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ATG14 Antibody

CAT: 0223-7043-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7043-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ATG14 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG14 is a subunit of a class III phosphatidylinositol (PtdIns) 3-kinase complex that targets the complex to the endoplasmic reticulum, the site of autophagosome formation.
NCBI Gene ID
22863
Swiss Prot
Q6ZNE5
Accession Number
NP_055739
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
ATG14 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Concentration
1 mg/mL
Buffer
ATG14 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ATG14 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
IgG
Specificity
At least three isoforms of ATG14 are known to exist; this antibody will detect all three isoforms
Symbol
ATG14
Positive Control 2
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
ATG14 autophagy related 14 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Gozuacik D and Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-906.
Background Reference 02
Kisen GO, Tessitore L, Costelli P, et al. Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells. Carcinogenesis 1993; 14:2501-5.
Background Reference 03
Kamada Y, Funakoshi T, Shintani T, et al. Tor-mediated induction of autophagy via Apg1 protein kinase complex. J. Cell. Biol. 2000; 150:1507-13.
Background Reference 04
Itakura E, Kishi C, Inoue K, et al. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 2008; 19:5360-72.
Other Product Names
ATG14 Antibody: ATG14L, BARKOR, KIAA0831, Beclin 1-associated autophagy-related key regulator, Autophagy-related protein 14-like protein, Barkor
Tested Applications
ELISA, WB, IF
Protein ID
50540545
Physical Properties
Liquid

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