CLEC2A Antibody

• Background:

  CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8 (+), B lymphocytes and naive CD4 (+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.

• NCBI Gene ID:

  387836

• Swiss Prot:

  Q6UVW9

• Accession Number:

  NP_001124183

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  CLEC2A Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1204 - K562 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  CLEC2A Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CLEC2A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  CLEC2A antibody is human specific. Two alternatively spliced transcript variants have been observed.

• Symbol:

  CLEC2A

• Positive Control 2:

  Cat. No. 17-004 - K-562 Cell Slide

• NCBI Official Name:

  C-type lectin domain family 2, member A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Huarte E, Cubillos-Ruiz JR, Nesbeth YC, et al. PILAR is a novel modulator of human T-cell expansion. Blood 2008; 112:1259-68.

• Background Reference 02:

  Drickamer K. C-type lectin-like domains. Curr. Opin. Struct. Biol. 1999; 9:585-90

• Background Reference 03:

  Spreu J, Kienle EC, Schrage B, et al. CLEC2A: a novel, alternatively spliced and skin-associated member of the NKC-encoded AICL-CD69-LLT1 family. Immunogenetics 2007; 59:903-12.

• Background Reference 04:

  Spreu J, Kuttruff S, Stejfova V, et al. Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes. Proc. Natl. Acad. Sci. USA 2010; 107:5100-5.

• Other Product Names:

  CLEC2A Antibody: KACL, PILAR, UNQ5792, KACL, UNQ5792/PRO19597, C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  195222725

• Physical Properties:

  Liquid