Products for Research Use Only
RegisterLogin

YPEL3 Antibody

CAT: 0223-6775-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-6775-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
YPEL3 Antibody: YPEL3 (yippee-like 3) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL3 is a p53-regulated gene whose expression is induced by DNA damage and in turn induces cellular senescence. It appears to function as a tumor suppressor as it is downregulated in colon and breast tumors.
NCBI Gene ID
83719
Swiss Prot
P61236
Accession Number
NP_113665
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
YPEL3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
YPEL3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
YPEL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
YPEL3
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Yippee-like 3
NCBI Organism
Homo sapiens
Background Reference 01
Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43.
Background Reference 02
Kelley K, Miller KR, Todd A, et al. YPEL3, a p53-regulated gene that induces cellular senescence. Cancer Res. 2010; 70:3566-75.
Background Reference 03
Tuttle R, Simon R, Hitch DC, et al. Senescence-associated gene YPEL3 is downregulated in human tumors. Ann. Surg. Oncol. 2011; 18:1791-6.
Background Reference 04
Tuttle R, Miller KR, Maiorano JN, et al. Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence. Int. J. Cancer 2011; epub.
Other Product Names
YPEL3 Antibody: Protein yippee-like 3
Tested Applications
ELISA, WB, ICC, IF
Protein ID
117956405
Physical Properties
Liquid

Related Products

CatalogName
6775PYPEL3 Peptide
6779-01mgYPEL5 Antibody
6777-01YPEL4 Antibody
6773-01YPEL2 Antibody
6777-01mgYPEL4 Antibody
6771-01YPEL1 Antibody
6773-01mgYPEL2 Antibody
6777-002mgYPEL4 Antibody
6779-002mgYPEL5 Antibody
6773-002mgYPEL2 Antibody

Alternative Products

CatalogName
MBS8594173-01YPEL3 Antibody
MBS8571234-01YPEL3 Polyclonal Antibody
CSB-CL026272HU1YPEL3

Popular Products