YPEL4 Antibody

• Background :

  YPEL4 Antibody: YPEL4 (yippee-like 4) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL4 is ubiquitously expressed in adult tissues and has been shown to associate with the major vault protein (MVP) . It has been suggested that MVP can inhibit YPEL4's ability to activate Elk-1 in the MAPK signaling pathway.

• NCBI Gene ID :

  219539

• Swiss Prot :

  Q96NS1

• Accession Number :

  NP_659445

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  YPEL4 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1221 - SW480 Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat: (100%)

• Buffer :

  YPEL4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  YPEL4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  YPEL4

• Positive Control 2 :

  Cat. No. 17-207 - EL4 Cell Slide

• NCBI Official Name :

  Yippee-like 4

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Hosono K, Sasaki T, Minoshima S, et al. Identification and characterization of a novel gene family YPEL in a wide spectrum of eukaryotic species. Gene 2004; 340: 31-43

• Background Reference 02 :

  Liang P, Wan Y, Yan Y, et al. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway. Biochem. Cell. Biol. 2010; 88:445-50.

• Other Product Names :

  YPEL4 Antibody: Protein yippee-like 4

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  21450727

• Physical Properties :

  Liquid