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TSHZ2 Antibody

CAT: 0223-6757-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6757-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TSHZ2 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Recent experiments have shown that the expression of TSHZ2 is frequently downregulated in most breast and prostate cancers and its promoter was unmethylated in virtually all cases, suggesting this family of proteins may also be involved in carcinogenesis.
NCBI Gene ID
128553
Swiss Prot
Q9NRE2
Accession Number
NP_775756
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
TSHZ2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (88%)
Buffer
TSHZ2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TSHZ2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TSHZ2
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Teashirt zinc finger homeobox 2
NCBI Organism
Homo sapiens
Background Reference 01
Caubit X, Core N, Boned A, et al. Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt. Mech. Dev. 2000; 91:445-8.
Background Reference 02
Santos JS, Fonseca NA, Vieira CP, et al. Phylogeny of the Teashirt-related zinc finger (tshz) gene family and analysis of the developmental expression of tshz2 and tshz3 in the zebrafish. Dev. Dyn. 2010; 239:1010-8.
Background Reference 03
Caubit X, Tiveron MC, Cremer H, et al. Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain. J. Comp. Neurol. 2005; 486:76-88.
Background Reference 04
Yamamoto M, Cid E, Bru S, et al. Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers. PLoS ONE 2011; 6:e17149.
Other Product Names
TSHZ2 Antibody: TSH2, ZABC2, ZNF218, OVC10-2, C20orf17, TSH2, Teashirt homolog 2, Ovarian cancer-related protein 10-2
Tested Applications
ELISA, WB, IF
Protein ID
153945734
Physical Properties
Liquid

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