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JMJD3 Antibody

CAT: 0223-6657-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6657-01Size:0.02 mg
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Background
JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.
NCBI Gene ID
23135
Swiss Prot
O15054
Accession Number
EAW90126
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
6657
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar JMJD3 expression profile in human, mouse and rat cell lines detected by two independent anti-IFN-beta antibodies that recognize different epitopes, 6657 against C-terminus domain and 14-618 against N-terminus domain. IFN-beta proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines6657 14-618
Field of Research
Stem Cell
Purification
JMJD3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
JMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
JMJD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody is specific for JMJD3 and will not recognize other JMJD proteins.
Isoform
Human JMJD3 has 2 isoforms, including isoform 1 (1682aa, 181kD) and isoform 2 (1643aa, 177kD) . Mouse JMJD3 has one isoform (1641aa, 176kD) and rat JMJD3 also has one isoform (1356aa, 146kD) . 6657 can detect human, mouse and rat.
Symbol
KDM6B
Positive Control 2
Cat. No. 17-004 - K-562 Cell Slide
Positive Control 3
Cat. No. 1204 - K562 Cell Lysate
Positive Control 4
Cat. No. 1288 - A-20 Cell Lysate
NCBI Official Name
Lysine (K) -specific demethylase 6B
NCBI Organism
Homo sapiens
Background Reference 01
Agger et al. Nature 2007; 449:731-4.
Background Reference 02
De Santa et al. Cell 2007; 130:1083-94.
Background Reference 03
Sola et al. PLoS One 2011; 6:e18421.
Other Product Names
JMJD3 Antibody: JMJD3, JMJD3, KIAA0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3
Tested Applications
ELISA, WB, ICC, IF
Protein ID
122937251
Physical Properties
Liquid

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