RKHD3 Antibody

RKHD3 Antibody: Rkhd3, also known as MEX3B is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd3, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd3 is thought to act as a mechanism to fine-tune mRNA regulation in early Xenopus development, and with Rkhd4, but not Rkhd1, will co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

84206

Q6ZN04

NP_780575

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

RKHD3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

RKHD3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RKHD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody is specific for RKHD3 and will not recognize the other RKHD3 family of proteins.

MEX3B

Mex-3 homolog B

Homo sapiens

Takada H, Kawana T, Ito Y, et al. The RNA-binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development. Dev. 2009; 136:2413-22

Draper BW, Mello CC, Bowerman B, et al. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell 1996; 87:205-16.

Liu J, Valencia-Sanchez MA, Hannon GJ, et al. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat. Cell Biol 2005; 7:719-23.

Buchet-Poyau K, Courchet J, Le Hir H, et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res. 2007; 35:1289-300.

RKHD3 Antibody: RKHD3, MEX-3B, RNF195, KIAA2009, RKHD3, RNA-binding protein MEX3B, RING finger and KH domain-containing protein 3

ELISA, WB, IF

47716512