LEMD3 Antibody

• Background :

  LEMD3 Antibody: LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.

• NCBI Gene ID :

  23592

• Swiss Prot :

  Q9Y2U8

• Accession Number :

  NP_055134

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  LEMD3 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1320 - Human Colon Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  LEMD3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  LEMD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2

• Symbol :

  LEMD3

• NCBI Official Name :

  LEM domain containing 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Hellemans J, Preobrazhenska O, Willaert A, et al. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. Nat. Genet. 2004; 36:1213-8.

• Other Product Names :

  LEMD3 Antibody: MAN1, MAN1, Inner nuclear membrane protein Man1, LEM domain-containing protein 3

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  7706607

• Physical Properties :

  Liquid