SLC35D2 Antibody

• Background:

  SLC35D2 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident SLC family member SLC35D2 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. Its overexpression in transfected cells modulated cell surface heparin sulfate expression, suggesting that SLC35D2 is involved in heparin sulfate synthesis. SLC35D2-overexpressing cells also showed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc, suggesting that SLC35D2 may be involved in UDP-sugar release and cell signaling.

• NCBI Gene ID:

  11046

• Swiss Prot:

  Q76EJ3

• Accession Number:

  NP_008932

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  SLC35D2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (80%)

• Buffer:

  SLC35D2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SLC35D2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least two isoforms of SLC35D2 are known to exist; this antibody will recognize both isoforms. SLC35D2 antibody is predicted to not cross-react with SLC35D1 or SLC35D3.

• Symbol:

  SLC35D2

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Solute carrier family 35, member D2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ishida N and Kawakita M. Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35) . Pflugers Arch. 2004; 447:768-75.

• Background Reference 02:

  Suda T, Kamiyama S, Suzuki M, et al. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. J. Biol. Chem. 2004; 279:26469-74

• Background Reference 03:

  Sesma JI, Esther Jr CR, Kreda SM, et al. Endoplasmic reticulum/Golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules. J. Biol. Chem. 2009; 284:12572-83.

• Other Product Names:

  SLC35D2 Antibody: hfrc, HFRC1, SQV7L, UGTrel8, HFRC, UGTREL8, Homolog of Fringe connection protein 1

• Tested Applications:

  ELISA, WB, ICC

• Protein ID:

  223029426

• Physical Properties:

  Liquid