CHD7 Antibody

• Background :

  CHD7 Antibody: CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.

• NCBI Gene ID :

  55636

• Swiss Prot :

  Q9P2D1

• Accession Number :

  Q9P2D1

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Stem Cell

• Purification :

  CHD7 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1220 - SK-N-SH Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  CHD7 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  CHD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  Multiple isoforms of CHD7 are known to exist.

• Symbol :

  CHD7

• NCBI Official Name :

  Chromodomain helicase DNA binding protein 7

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Woodage T, Basrai MA, Baxevanis AD, et al. Characterization of the CHD family of proteins. Proc. Natl. Acad. Sci. USA 1997; 94:11472-7.

• Background Reference 02 :

  Cavalli G and Paro R. Chromo-domain proteins: linking chromatin structure to epigenetic regulation. Curr. Opin. Cell Biol. 1998; 10:354-60.

• Background Reference 03 :

  Vissers LE, van Ravenswaaj CM, Admiraal R, et al. Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. Nat. Genet. 2004; 36:955-7.

• Background Reference 04 :

  Schnetz MP, Handoko L, Akhtar-Zaidi B, et al. CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet. 2010; 6:31001023.

• Other Product Names :

  CHD7 Antibody: CRG, HH5, IS3, KAL5, KIAA1416, Chromodomain-helicase-DNA-binding protein 7, ATP-dependent helicase CHD7, CHD-7

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  54112403

• Physical Properties :

  Liquid