CHD3 Antibody

• Background :

  This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

• NCBI Gene ID :

  1107

• Swiss Prot :

  Q12873

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human CHD3 (NP_001005273.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  Affinity purification

• Positive Control :

  Jurkat

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 280kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:200 - 1:1000

• Symbol :

  CHD3

• Positive Control 2 :

  Mouse brain

• Positive Control 3 :

  Rat brain

• NCBI Official Name :

  Chromodomain helicase DNA binding protein 3

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  Mi-2a, Mi2-ALPHA, SNIBCPS, ZFH, chromodomain-helicase-DNA-binding protein 3, ATP-dependent helicase CHD3, CHD-3, hZFH, mi-2 autoantigen 240 kDa protein, zinc finger helicase, zinc-finger helicase (Snf2-like)

• Tested Applications :

  WB

• Physical Properties :

  Liquid