RegisterLogin

SPRYD2 Antibody

CAT: 0223-6403-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#: 6403-01Size: 0.02 mg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
SPRYD2 Antibody: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.
NCBI Gene ID
202333
Swiss Prot
Q8N3K9
Accession Number
NP_705838
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
SPRYD2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
SPRYD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SPRYD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.
Symbol
CMYA5
NCBI Official Name
Cardiomyopathy associated 5
NCBI Organism
Homo sapiens
Background Reference 01
Benson MA, Tinsley CL, Blake DJ. Myospryn is a novel binding partner for dysbindin in muscle. J. Biol. Chem. 2004; 279:10450-8.
Background Reference 02
Sarparanta J. Biology of myospryn: what's known? J. Muscle Res. Cell Motil. 2008; 29:177-80
Background Reference 03
Durham JT, Brand OM, Arnold M, et al. Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein. J. Biol. Chem. 2006; 281:6841-9
Background Reference 04
Kielbasa OM, Reynolds JG, Wu CL, et al. Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration. FASEB J. 2011 epub.
Other Product Names
SPRYD2 Antibody: SPRYD2, TRIM76, C5orf10, DTNBP2, SPRYD2, Cardiomyopathy-associated protein 5, Dystrobrevin-binding protein 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
62241003
Physical Properties
Liquid

Related Products

CatalogName
6403PSPRYD2 Peptide
6409-002mgSPRYD5 Antibody
4849-01mgSpred2 Antibody
6405-01mgSPRYD3 Antibody
6407-002mgSPRYD4 Antibody
6409-01SPRYD5 Antibody
6409-01mgSPRYD5 Antibody
6405-002mgSPRYD3 Antibody
4849-01Spred2 Antibody
6407-01SPRYD4 Antibody

Alternative Products

CatalogName
MBS150809-01SPRYD2 Antibody
254492SPRYD2 Antibody
25328SPRYD2 Antibody
MBS9406027-01SPRYD2 Antibody
APR06711GPolyclonal SPRYD2 Antibody
MBS151927-01SPRYD2 Peptide
A08262Anti-SPRYD2 CMYA5 Antibody
146869CMYA5 (Cardiomyopathy-associated Protein 5, Dystrobrevin-binding Protein 2, Genethonin-3, Myospryn, SPRY Domain-containing Protein 2, Tripartite Motif-containing Protein 76, C5orf10, DTNBP2, SPRYD2, TRIM76)
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody

Popular Products