SPRYD2 Antibody

• Background :

  SPRYD2 Antibody: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.

• NCBI Gene ID :

  202333

• Swiss Prot :

  Q8N3K9

• Accession Number :

  NP_705838

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Homeostasis

• Purification :

  SPRYD2 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  SPRYD2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  SPRYD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.

• Symbol :

  CMYA5

• NCBI Official Name :

  Cardiomyopathy associated 5

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Benson MA, Tinsley CL, Blake DJ. Myospryn is a novel binding partner for dysbindin in muscle. J. Biol. Chem. 2004; 279:10450-8.

• Background Reference 02 :

  Sarparanta J. Biology of myospryn: what's known? J. Muscle Res. Cell Motil. 2008; 29:177-80

• Background Reference 03 :

  Durham JT, Brand OM, Arnold M, et al. Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein. J. Biol. Chem. 2006; 281:6841-9

• Background Reference 04 :

  Kielbasa OM, Reynolds JG, Wu CL, et al. Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration. FASEB J. 2011 epub.

• Other Product Names :

  SPRYD2 Antibody: SPRYD2, TRIM76, C5orf10, DTNBP2, SPRYD2, Cardiomyopathy-associated protein 5, Dystrobrevin-binding protein 2

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  62241003

• Physical Properties :

  Liquid