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Spred2 Antibody

CAT: 0223-4849-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4849-01Size:0.02 mg
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Background
Spred2 Antibody: Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.
NCBI Gene ID
200734
Swiss Prot
Q7Z698
Accession Number
NP_861449
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Spred2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (85%), Rat: (85%)
Buffer
Spred2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Spred2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.
Symbol
SPRED2
NCBI Official Name
Sprouty-related, EVH1 domain containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Wakioka T, Sasaki A, Kato R, et al. Spred is a Sprouty-related suppressor of Ras signalling. Nature2001; 412:647-51.
Background Reference 02
Casci T, Vinos J, and Freeman M. Sprouty, an intracellular inhibitor of Ras signaling. Cell1999; 96:655-65.
Background Reference 03
Minowada G, Jarvis LA, Chi CL, et al. Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development1999; 126:4465-75.
Background Reference 04
Lee SH, Schloss DJ, Jarvis L, et al. Inhibition of angiogenesis by a mouse sprouty protein. J. Biol. Chem.2001; 276:4128-33.
Other Product Names
Spred2 Antibody: Spred-2, Sprouty-related, EVH1 domain-containing protein 2, Spred-2
Tested Applications
ELISA, WB
Protein ID
189571669
Physical Properties
Liquid

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