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SGK1 Antibody

CAT: 0223-6319-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6319-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SGK1 Antibody: Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1.3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
NCBI Gene ID
6446
Swiss Prot
O00141
Accession Number
NP_005618
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
SGK1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1319 - Human Stomach Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (89%), Chicken: (84%), Rabbit: (89%)
Buffer
SGK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SGK1 antibody can be stored at 4 ˚ C for 3 months and -20 ˚ C stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist
Symbol
SGK1
Positive Control 2
Cat. No. 10-801 - Human Stomach Tissue Slide
NCBI Official Name
Serum/glucocorticoid regulated kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Webster MK, Goya L, Ge Y, et al. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell Biol. 1993; 13:2031-40.
Background Reference 02
Leong ML, Maiyar AC, Kim B, et al. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J. Biol. Chem. 2003; 278:5871-82.
Background Reference 03
Firestone GL, Giampaolo JR, O'Keeffe BA, et al. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell. Physiol. Biochem. 2003; 13:1-12.
Background Reference 04
Brunet A, Park J, Tran H, et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) . Mol. Cell Biol. 2001; 21:952-65.
Other Product Names
SGK1 Antibody: SGK, SGK
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
25168263
Physical Properties
Liquid

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