SIK2 Antibody

CAT: 0223-6301-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6301-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC) . SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
NCBI Gene ID
23235
Swiss Prot
Q9H0K1
Accession Number
EAW67148
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
SIK2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1221 - SW480 Cell Lysate
Concentration
1 mg/mL
Buffer
SIK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SIK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
SIK2 antibody is predicted to not cross-react with other SIK protein family members.
Symbol
SIK2
NCBI Official Name
Salt-inducible kinase 2
NCBI Organism
Homo sapiens
Background Reference 01
Horike N, Takemori H, Katoh Y, et al. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J. Biol. Chem. 2003; 278:18440-7.
Background Reference 02
Screaton RA, Conkright MD, Katoh Y, et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 2004; 119:61-74.
Background Reference 03
Muraoka M, Fukushima A, Viengchareun S, et al. Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes. Am. J. Physiol. Endocrinol. Metab. 2009; 296:E1430-9.
Background Reference 04
Sasaki T, Takemori H, Yagita Y, et al. SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB. Neuron 2011; 69:106-19.
Other Product Names
SIK2 Antibody: QIK, SNF1LK2, LOH11CR1I, KIAA0781, QIK, Qin-induced kinase, SIK-2
Tested Applications
ELISA, WB, ICC, IF
Protein ID
38569460
Physical Properties
Liquid

Related Products

CatalogName
6301PSIK2 Peptide
61-907SIKE Antibody
6299-002mgSIK1 Antibody
6613-01SIK3 Antibody
6299-01mgSIK1 Antibody
6613-01mgSIK3 Antibody
6299-01SIK1 Antibody
6613-002mgSIK3 Antibody
59-731Sik1 Antibody
6613PSIK3 Peptide

Alternative Products

CatalogName
C46275-01SIK2 Antibody
abx376448-01Serine/threonine-Protein Kinase SIK2 (SIK2) Antibody
MBS8531235-01SIK2 Polyclonal Antibody
STJ191985Anti-SIK2 antibody
MBS9205867-01SIK2 Antibody (Center)
MBS8536693-01SIK2

Popular Products