ATP2C2 Antibody

CAT: 0223-6289-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6289-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
NCBI Gene ID
9914
Swiss Prot
O75185
Accession Number
NP_055676
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ATP2C2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
1 mg/mL
Buffer
ATP2C2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ATP2C2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1
Symbol
ATP2C2
Positive Control 2
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
ATPase, Ca++ transporting, type 2C, member 2
NCBI Organism
Homo sapiens
Background Reference 01
Xiang M, Mohamalawari D, and Rao R. A novel isoform of the secretory pathway Ca2+, Mn (2+) -ATPase, hSPCA2, has unusual properties and is expressed in the brain. J. Biol. Chem. 2005; 280:11608-14.
Background Reference 02
Hu Z, Bonifas JM, Beech J, et al. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat. Genet. 2000; 24:61-5
Background Reference 03
Dode L, Andersen JP, Vanoevelen J, et al. Dissection of the functional differences between human secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and 2 isoenzymes by steady-state and transient kinetic analyses. J. Biol. Chem. 281:3182-9.
Other Product Names
ATP2C2 Antibody: SPCA2, KIAA0703, SPCA2, Calcium-transporting ATPase type 2C member 2, ATPase 2C2
Tested Applications
ELISA, WB, IF
Protein ID
118498343
Physical Properties
Liquid

Related Products

CatalogName
6289PATP2C2 Peptide
6287-002mgATP2C1 Antibody
6287-01ATP2C1 Antibody
58-877ATP2A2 Antibody
6287-01mgATP2C1 Antibody
22-523ATP2B2 Antibody
43-428SERCA2 / ATP2A2 Antibody
13-031ATP2A2 / SERCA2 Antibody
13-873ATP2A2 / SERCA2 Antibody
63-851ATP5C1 Antibody

Alternative Products

CatalogName
MBS9609629-01ATP2C2 Antibody
APG02104GPolyclonal ATP2C2 Antibody
A09207Anti-ATP2C2 Antibody
NBP2-14329Rabbit Polyclonal ATP2C2 Antibody
A13495-100ULATP2C2 Antibody, HRP conjugated
A13497-100ULATP2C2 Antibody, Biotin conjugated
MBS7112778-01ATP2C2 Antibody, FITC Conjugated
555926-01ATP2C2
555927-01ATP2C2 (Biotin)
DF9312-BPATP2C2 Peptide

Popular Products