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EZH1 Antibody

CAT: 0223-6261-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6261-01Size:0.02 mg
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Background
EZH1 Antibody: EZH1 was initially identified as a homolog of the drosophila Enhancer of Zeste through transcription mapping of chromosome 17q21. Both EZH1 and the related protein EZH2 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair.
NCBI Gene ID
2145
Swiss Prot
Q92800
Accession Number
AAC50778
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
EZH1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1402 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
EZH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
EZH1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Multiple isoforms of EZH1 are known to exist. EZH1 antibody is predicted to not cross-react with EZH2
Symbol
EZH1
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Enhancer of zeste homolog 1
NCBI Organism
Homo sapiens
Background Reference 01
Abel KJ, Brody LC, Valdes JM, et al. Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. Genomics 1996; 37:161-71
Background Reference 02
Margueron R, Li G, Sarma K, et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol. Cell 2008; 32:503-18.
Background Reference 03
Shen X, Liu Y, Hsu YJ, et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol. Cell 2008; 32:491-502
Background Reference 04
Ezhkova E, Lien WH, Stokes N, et al. EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Genes Dev. 2011; 25:485-98
Other Product Names
EZH1 Antibody: KMT6B, KIAA0388, Histone-lysine N-methyltransferase EZH1, ENX-2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
19923202
Physical Properties
Liquid

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