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SLAMF4 Antibody

CAT: 0223-6253-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6253-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SLAMF4 Antibody: The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.
NCBI Gene ID
51744
Swiss Prot
Q9BZW8
Accession Number
NP_1160135
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
SLAMF4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1224 - Daudi Cell Lysate
Concentration
1 mg/mL
Buffer
SLAMF4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLAMF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.
Symbol
CD244
NCBI Official Name
CD244 molecule, natural killer cell receptor 2B4
NCBI Organism
Homo sapiens
Background Reference 01
Claus M, Meinke S, Bhat R, et al. Regulation of NK cell activity by 2B4, NTB-A and CRACC. Front. Biosci. 2008; 13:956-65.
Background Reference 02
Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.
Background Reference 03
Assarsson E, Kambayashi T, Persson CM, et al. 2B4/CD48-mediated regulation of lymphocyte activation and function. J. Immunol. 2005; 175:2045-9
Background Reference 04
Kim JR, Matther SO, Patel RK, et al. Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythmatosus. Clin. Exp. Immunol. 2010; 160:348-58
Other Product Names
SLAMF4 Antibody: 2B4, NAIL, Nmrk, NKR2B4, SLAMF4, 2B4, Natural killer cell receptor 2B4, NK cell activation-inducing ligand
Tested Applications
ELISA, WB, IF
Protein ID
7706529
Physical Properties
Liquid

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