LRRTM2 Antibody

• Background:

  LRRTM2 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.

• NCBI Gene ID:

  26045

• Swiss Prot:

  O43300

• Accession Number:

  EAW62125

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  LRRTM2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1220 - SK-N-SH Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  LRRTM2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  LRRTM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  LRRTM2 antibody is predicted to not cross-react with other LRRTM family members.

• Symbol:

  LRRTM2

• Positive Control 2:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Leucine rich repeat transmembrane neuronal 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.

• Background Reference 02:

  Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.

• Background Reference 03:

  Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.

• Background Reference 04:

  Ko J, Fuccillo MV, Malenka RC, et al. LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron 2009; 64:791-8.

• Other Product Names:

  LRRTM2 Antibody: KIAA0416, LRRN2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  7662102

• Physical Properties:

  Liquid