LRRTM2 Antibody

CAT: 0223-6169-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6169-01Size:0.02 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LRRTM2 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
NCBI Gene ID
26045
Swiss Prot
O43300
Accession Number
EAW62125
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
LRRTM2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Buffer
LRRTM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LRRTM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
LRRTM2 antibody is predicted to not cross-react with other LRRTM family members.
Symbol
LRRTM2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Leucine rich repeat transmembrane neuronal 2
NCBI Organism
Homo sapiens
Background Reference 01
Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.
Background Reference 02
Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.
Background Reference 03
Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.
Background Reference 04
Ko J, Fuccillo MV, Malenka RC, et al. LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron 2009; 64:791-8.
Other Product Names
LRRTM2 Antibody: KIAA0416, LRRN2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7662102
Physical Properties
Liquid

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