LRRTM4 Antibody

• Background :

  LRRTM4 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Little is known about the function of LRRTM4; in mouse, it is expressed in the limb mesenchyme, neural tube, caudal mesoderm and in three distinct regions of the head. Later expression occurs in a subset of the developing sclerotome. Its similarity to other LRRTM family members suggests that LRRTM4 may also play a role in the development and maintenance of the vertebrate nervous system.

• NCBI Gene ID :

  80059

• Swiss Prot :

  Q86VH4

• Accession Number :

  NP_001128217

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  LRRTM4 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse: (93%), Rat: (91%)

• Buffer :

  LRRTM4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  LRRTM4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  At least two isoforms of LRRTM4 are known to exist; this antibody will both isoforms. LRRTM4 antibody is predicted to not cross-react with other LRRTM family members.

• Symbol :

  LRRTM4

• Positive Control 2 :

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name :

  Leucine rich repeat transmembrane neuronal 4

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21.

• Background Reference 02 :

  Linhoff MW, Lauren J, Cassidy RM, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron 2009; 61:734-49.

• Background Reference 03 :

  Siddiqui TJ, Pancaroglu R, Kang Y, et al. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J. Neurosci. 2010; 30:7495-506.

• Background Reference 04 :

  Haines BP and Rigby PW. Developmentally regualted expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr. Patterns 2007; 7:23-9.

• Other Product Names :

  LRRTM4 Antibody: Leucine-rich repeat transmembrane neuronal protein 4

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  156139147

• Physical Properties :

  Liquid