ZBTB6 Antibody

• Background:

  ZBTB6 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB6, also known as ZNF482, is highly expressed in brain. While little is known about ZBTB6, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB family member, ZBTB5, also acts as a transcriptional repressor, and can interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, suggesting that ZBTB6 may also act as a transcriptional repressor.

• NCBI Gene ID:

  10773

• Swiss Prot:

  Q15916

• Accession Number:

  AAH37282

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  ZBTB6 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (81%)

• Buffer:

  ZBTB6 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZBTB6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least two isoforms of ZBTB6 are known to exist; this antibody will only recognize the shorter isoform. This antibody is predicted to not cross-react with other ZBTB protein family members.

• Symbol:

  ZBTB6

• Positive Control 2:

  Cat. No. 17-207 - EL4 Cell Slide

• NCBI Official Name:

  Zinc finger and BTB domain containing 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. USA2002; 99:16899-903.

• Background Reference 02:

  Filion GJP, Zhenilo S, Salozhin S, et al. A family of zinc finger proteins that bind methylated DNA and repress transcription. Mol. Cell. Biol.2006; 26:169-81.

• Background Reference 03:

  Koh D, Choi W, Jeon B, et al. A novel POK family transcription factor, ZBTB5, represses transcription of p21CIP1 gene. J. Biol. Chem.2009; 284:19856-66.

• Other Product Names:

  ZBTB6 Antibody: ZID, ZNF482, ZID, Zinc finger and BTB domain-containing protein 6, Zinc finger protein 482

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  5730122

• Physical Properties:

  Liquid