PLAC4 Antibody

• Background:

  PLAC4 Antibody: PLAC4 (placenta-specific protein 4), was initially discovered as a gene whose mRNA was expressed in placental syncytiotrophoblast and choriocarcinoma cells. While the function of PLAC4 is currently unclear, its gene is known to be located on chromosome 21q22.3. Due to the PLAC4 gene location on chromosome 21 and the release of its mRNA transcripts into maternal bloodstream from the placenta, it has been proposed to be a useful marker noninvasive prenatal chromosome 21 aneuploidy detection, although other reports suggests that PLAC4 mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21.

• NCBI Gene ID:

  191585

• Swiss Prot:

  Q8WY50

• Accession Number:

  NP_878252

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  PLAC4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1309 - Human Placenta Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PLAC4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PLAC4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PLAC4

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Placenta-specific 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kido S, Sakuragi N, Bronner MP, et al. D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma. Genomics1993; 17:256-9.

• Background Reference 02:

  Lo YMD, Tsui NBY, Chiu RWK, et al. Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection. Nat. Med.2007; 13:218-223.

• Background Reference 03:

  Tsui NB, Akolekar R, Chiu RW, et al. Synergy of total PLAC4 RNA concentration and measurement of the RNA single-nucleotide polymorphism allelic ratio for the noninvasive prenatal detection of trisomy 21. Clin. Chem.2010; 56:73-81.

• Background Reference 04:

  Banzola I, Rusterholz C, Zannoni L, et al. PLAC4 and beta-HCG mRNA levels are not altered in the maternal circulation of pregnancies with trisomy 21. Prenat. Diagn.2008; 28:1262-7.

• Other Product Names:

  PLAC4 Antibody: PRED78, C21orf115, D21S418E, PP1416, Placenta-specific protein 4

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  121949815

• Physical Properties:

  Liquid