KPNA4 Antibody

• Background:

  KPNA4 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. Molecules containing the classical nuclear localization signal (NLS) are transported into the nucleus by alpha/beta heterodimers. KPNA3 has been shown to be important in the TNF-α -induced nuclear import of NF-κ B. It is also involved in the stress-mediated nuclear stabilization of p53 and the nuclear import and replication of HIV-1 in both dividing and non-dividing cells.

• NCBI Gene ID:

  3840

• Swiss Prot:

  O00629

• Accession Number:

  EAW78632

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  KPNA4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1304 - Human Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  KPNA4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  KPNA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  KPNA4

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Karyopherin alpha 4 (importin alpha 3)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene Expr.1997; 7:61-72.

• Background Reference 02:

  Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem.2003; 278: 51937-49.

• Background Reference 03:

  Goldfarb DS, Corbett AH, Mason DA, et al. Importin alpha: a multi-purpose nuclear-transport receptor. Trends Cell Biol.2004; 14:505-14.

• Background Reference 04:

  Fagerlund R, Melen K, Cao X, et al. NF-kappaB p52, RelB, and c-Rel are transported into the nucleus via a subset of importin alpha molecules. Cell Signal.2008; 20:1442-51.

• Other Product Names:

  KPNA4 Antibody: QIP1, SRP3, IPOA3, QIP1, Importin subunit alpha-3, Importin alpha Q1, Qip1

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  119599038

• Physical Properties:

  Liquid