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NALP10 Antibody

CAT: 0223-5967-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5967-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NALP10 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1β , inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1β processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
NCBI Gene ID
338322
Swiss Prot
Q86W26
Accession Number
NP_789791
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
NALP10 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (83%)
Buffer
NALP10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NALP10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NLRP10
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
NLR family, pyrin domain containing 10
NCBI Organism
Homo sapiens
Background Reference 01
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Background Reference 02
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Background Reference 03
Wang Y, Hasegawa M, Imamura R, et al. PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. Int. Immunol.2004; 16:777-86.
Background Reference 04
Imamura R, Wang Y, Kinoshita T, et al. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J. Immunol.2010; 184:5874-84.
Other Product Names
NALP10 Antibody: NOD8, PAN5, PYNOD, NALP10, CLR11.1, NOD8, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
28827807
Physical Properties
Liquid

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