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SCUBE1 Antibody

CAT: 0223-5843-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5843-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SCUBE1 Antibody: SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.
NCBI Gene ID
80274
Swiss Prot
Q8IWY4
Accession Number
NP_766638
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
SCUBE1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1224 - Daudi Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (93%)
Buffer
SCUBE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SCUBE1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SCUBE1
NCBI Official Name
Signal peptide, CUB domain, EGF-like 1
NCBI Organism
Homo sapiens
Background Reference 01
Grimmond S, Larder R, Van Hateren N, et al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1) . Genomics2000; 70:74-81.
Background Reference 02
Tu C, Yan Y, Wu S, et al. Domain and function analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J. Biol. Chem.2008; 283:12478-88.
Background Reference 03
Xaiver GM, Sharpe PT, and Colbourne MT. Scube1 is expressed during facial development in the mouse. J. Exp. Zool. B. Mol. Dev. Evol.2009; 312B:518-24.
Other Product Names
SCUBE1 Antibody: Signal peptide, CUB and EGF-like domain-containing protein 1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
120587029
Physical Properties
Liquid

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