ZEB1 Antibody

• Background:

  ZEB1 Antibody: ZEB1, initially identified as the delta-crystallin enhancer binding protein delta EF1, is a DNA-binding protein that binds to a modified E-box sequence and has been implicated in postgastrulation embryogenesis. ZEB1 binds to the promoter of several hemapoietic genes, including interleukin-2, CD4, GATA-3, and alpha-integrin, and mice in which ZEB1 has been targeted show thymic atrophy, and severe defects in lymphocyte differentiation. Recent evidence suggests that ZEB1 also regulates the accumulation of adipose tissue and may play a role in obesity. Mutations in this gene have been associated with late-onset Fuchs endothelial corneal dystrophy.

• NCBI Gene ID:

  6935

• Swiss Prot:

  P37275

• Accession Number:

  NP_110378

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  ZEB1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  ZEB1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZEB1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  Multiple isoforms of ZEB1 are known to exist.

• Symbol:

  ZEB1

• Positive Control 2:

  Cat. No. 10-201 - Human Liver Tissue Slide

• Positive Control 3:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Zinc finger E-box binding homeobox 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Funahashi J, Sekido R, Murai K, et al. Delta-crystallin enhancer protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Dev.1993; 119:433-46.

• Background Reference 02:

  Postigo AA and Dean DC. Independent repressor domains in ZEB regulate muscle and T-cell differentiation. Mol. Cell Biol.1999; 19:7961-71.

• Background Reference 03:

  Saykally JN, Dogan S, Cleary MP, et al. The ZEB1 transcription factor is a novel repressor of adiposity in female mice. PLos One2009; 4:e8460.

• Background Reference 04:

  Mehta JS, Vithana EN, Tan DT, et al. Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. Invest. Opthalmol. Vis. Sci.2008; 49:184-8.

• Other Product Names:

  ZEB1 Antibody: BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1, Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, TCF-8

• Tested Applications:

  ELISA, WB, IHC-P, ICC, IF

• Protein ID:

  55957123

• Physical Properties:

  Liquid