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PIAS2 Antibody

CAT: 0223-5743-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5743-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PIAS2 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.
NCBI Gene ID
9063
Swiss Prot
O75928
Accession Number
EAX01485
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
PIAS2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
PIAS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PIAS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PIAS2
NCBI Official Name
Protein inhibitor of activated STAT, 2
NCBI Organism
Homo sapiens
Background Reference 01
Shuai K and Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.
Background Reference 02
Arora T, Liu B, He H, et al. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J. Biol. Chem.2003; 278:21327-30.
Background Reference 03
Patel JH and McMahon SB. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. J. Biol. Chem.2007; 282:5-13.
Background Reference 04
Saito M, Novak U, Piovan E, et al. BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA2009; 106:11294-9.
Other Product Names
PIAS2 Antibody: DIP, MIZ, MIZ1, SIZ2, ARIP3, PIASX, ZMIZ4, PIASX-BETA, PIASX-ALPHA, E3 SUMO-protein ligase PIAS2, Androgen receptor-interacting protein 3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
119621890
Physical Properties
Liquid

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