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APC11 Antibody

CAT: 0223-5737-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5737-01Size:0.02 mg
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Background
APC11 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.
NCBI Gene ID
51529
Swiss Prot
Q9NYG5
Accession Number
NP_001002244
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
APC11 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
APC11 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
APC11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ANAPC11
Positive Control 2
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
Anaphase promoting complex subunit 11
NCBI Organism
Homo sapiens
Background Reference 01
JM Peters. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol.2006; 7:644-56.
Background Reference 02
Jorgensen PM, Graslund S, Betz R, et al. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene2001; 262:51-9.
Background Reference 03
Tan Z, Li B, Bharadwaj R, et al. APC Cullin protein and APC RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol. Biol. Cell2001; 12:3839-51.
Other Product Names
APC11 Antibody: APC11, Apc11p, HSPC214, Anaphase-promoting complex subunit 11, Cyclosome subunit 11, APC11
Tested Applications
ELISA, WB, IF
Protein ID
50409810
Physical Properties
Liquid

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