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APC10 Antibody

CAT: 0223-5735-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5735-01Size:0.02 mg
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Background
APC10 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.
NCBI Gene ID
10393
Swiss Prot
Q9UM13
Accession Number
EAX05052
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
APC10 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1401 - Mouse Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
APC10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
APC10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ANAPC10
NCBI Official Name
Anaphase promoting complex subunit 10
NCBI Organism
Homo sapiens
Background Reference 01
JM Peters. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol.2006; 7:644-56.
Background Reference 02
Jorgensen PM, Graslund S, Betz R, et al. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Gene2001; 262:51-9.
Background Reference 03
Passmore LA, McCormack EA, Au SWN, et al. Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J.2003; 22:786-96.
Other Product Names
APC10 Antibody: DOC1, APC10, Anaphase-promoting complex subunit 10, Cyclosome subunit 10
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
119625457
Physical Properties
Liquid

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