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SRPX2 Antibody

CAT: 0223-5475-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5475-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SRPX2 Antibody: Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.
NCBI Gene ID
27286
Swiss Prot
O60687
Accession Number
NP_055282
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
SRPX2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
SRPX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SRPX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
SRPX2
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Sushi-repeat-containing protein, X-linked 2
NCBI Organism
Homo sapiens
Background Reference 01
Roll P, Rudolf G, Pereira S, et al. SRPX2 mutations in disorders of language cortex and cognition. Hum. Mol. Genet.2006; 15:1195-207.
Background Reference 02
Miljkovic-Licina M, Hammel P, Garrido-Urbani S, et al. Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J.2009; 23:4105-16.
Background Reference 03
Blasi F and Carmeliet P. uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell. Biol.2002; 3:932-43.
Background Reference 04
Tanaka K, Arao T, Maegawa M, et al. SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion. Int. J. Cancer2009; 124:1072-80.
Other Product Names
SRPX2 Antibody: BPP, CBPS, PMGX, RESDX, SRPUL, Sushi repeat-containing protein SRPX2, Sushi-repeat protein upregulated in leukemia
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7657619
Physical Properties
Liquid

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