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GOLPH3 Antibody

CAT: 0223-5443-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5443-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GOLPH3 Antibody: GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signalling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signalling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.
NCBI Gene ID
64083
Swiss Prot
Q9H4A6
Accession Number
AAH12123
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
GOLPH3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1462 - Rat Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
GOLPH3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GOLPH3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
GOLPH3
NCBI Official Name
Golgi phosphoprotein 3 (coat-protein)
NCBI Organism
Homo sapiens
Background Reference 01
Bell AW, Ward MA, Blackstock WP, et al. Proteomics characterization of abundant Golgi membrane proteins. J. Biol. Chem.2001; 276:5152-65.
Background Reference 02
Nakashima-Kamimura N, Asoh S, Ishibashi Y, et al. MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J. Cell Sci.2005; 118:5357-67.
Background Reference 03
Scott KL, Kabbarah O, Liang M-C, et al. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature2009; 459:1085-90.
Other Product Names
GOLPH3 Antibody: GOPP1, GPP34, MIDAS, Golgi phosphoprotein 3, Coat protein GPP34
Tested Applications
ELISA, WB, IF
Protein ID
15082415
Physical Properties
Liquid

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