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ATOH8 Antibody

CAT: 0223-5109-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5109-01Size:0.02 mg
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Background
ATOH8 Antibody: Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
NCBI Gene ID
84913
Swiss Prot
Q96SQ7
Accession Number
NP_116216
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
ATOH8 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
ATOH8 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ATOH8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ATOH8
NCBI Official Name
Atonal homolog 8 (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Wasserman SM, Mehraban F, Komuves LG, et al. Gene expression profile of human endothelial cells exposed to sustained fluid shear stress. Physiol. Genomics 2002;12:13-23.
Background Reference 02
Ledent V and Vervoort M. The basic helix-loop-helix protein family: comparative genomics and phylogenetic analysis. Genome Res. 2001; 11:754-770.
Background Reference 03
Inoue C, Bae SK, Takatsuka K, et al. Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation. Genes Cells 2001; 6:977-986.
Background Reference 04
Ross MD, Martinka S, Mukherjee A, et al. Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis. Dev Dyn. 2006; 235:3102-3109.
Other Product Names
ATOH8 Antibody: HATH6, bHLHa21, ATH6, BHLHA21, Protein atonal homolog 8, Class A basic helix-loop-helix protein 21
Tested Applications
ELISA, WB, IHC-P
Protein ID
226498192
Physical Properties
Liquid

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