ZIP10 Antibody

CAT: 0223-4991-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-4991-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ZIP10 Antibody: ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.
NCBI Gene ID
363229
Swiss Prot
Q9ULF5
Accession Number
EAW70116
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
ZIP10 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
ZIP10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZIP10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody will not cross-react with the zinc transporter ZIP11.
Symbol
Slc39a10
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Solute carrier family 39 (zinc transporter), member 10
NCBI Organism
Rattus norvegicus
Background Reference 01
Kaler P and Prasad R. Molecular cloning and functional characterization of novel transporter rZip10 (Slc39a10) involved in zinc uptake across renal brush-border membrane. Am. J. Renal Physiol.2007; 292:F217-29.
Background Reference 02
Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
Background Reference 03
Pawan K, Neeraj S, Sandeep K, et al. Upregulation of Slc39a10 gene expression in response to thyroid hormones in intestine and kidney. Biochim. Biophys. Acta.2007; 1769:117-23.
Background Reference 04
Kagara N, Tanaka N, Noguchi S, et al. Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci.2007; 98:692-7.
Other Product Names
ZIP10 Antibody:
Tested Applications
ELISA, WB, IHC-P
Protein ID
149046180
Physical Properties
Liquid

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