TREX2 Antibody

• Background:

  TREX2 Antibody: TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.

• NCBI Gene ID:

  11219

• Swiss Prot:

  Q9BQ50

• Accession Number:

  Q9BQ50

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  TREX2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TREX2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TREX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  This TREX2 antibody will not cross-react with the related protein TREX1.

• Symbol:

  TREX2

• Positive Control 2:

  Cat. No. 10-201 - Human Liver Tissue Slide

• NCBI Official Name:

  Three prime repair exonuclease 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mazur DJ and Perrino FW. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3→5 exonucleases. J. Biol. Chem.1999; 274:19655-60.

• Background Reference 02:

  Cortez D, Guntuku S, Qin J, et. al. ATR and ATRIP: partners in checkpoint signaling. Science2001; 294:1713-6

• Background Reference 03:

  Crow YJ, Hayward BE, Parmar R, et al. Mutations in the gene encoding the 3-5DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat. Genet. 2006; 38:917-20

• Background Reference 04:

  Mazur DJ and Perrino FW. Structure and expression of the TREX1 and TREX2 3'→5' exonuclease genes. J. Biol. Chem.2001; 276:14718-27.

• Other Product Names:

  TREX2 Antibody: Three prime repair exonuclease 2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  47606206

• Physical Properties:

  Liquid