LASS6 Antibody

• Background :

  LASS6 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. Like the highly homologous LASS5, LASS6 is also an endoplasmic reticulum, multi-pass membrane protein. LASS6 is also involved in the synthesis of C14, C16 and C18-ceramide, but shows a preference for unsaturated fatty acids. LASS6 is broadly expressed in a wide range of tissues and microarray data suggests that it may play a role in cancer differentiation and early embryonic development.

• NCBI Gene ID :

  253782

• Swiss Prot :

  Q6ZMG9

• Accession Number :

  AAI09285

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Homeostasis

• Purification :

  LASS6 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  LASS6 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  LASS6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  At least two isoforms of LASS6 are known to exist. This antibody is predicted not to cross-react with LASS5.

• Symbol :

  CERS6

• NCBI Official Name :

  Ceramide synthase 6

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Riebeling C, Allegood JC, Wang E, et al. Two mammalian longevity assurance gene (LAG1) family members, Trh1 and Trh, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J. Biol. Chem.2003; 278:43452-9.

• Background Reference 02 :

  Mizutani Y, Kihara A and Igarashi Y. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Biochem. J.2005; 390:263-71.

• Background Reference 03 :

  Lahiri S and Futerman AH. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J. Biol Chem.2005; 280:33735-8.

• Background Reference 04 :

  Weinmann A, Galle PR, and Teufel A. LASS6, an additional member of the longevity assurance gene family. Int. J. Mol. Med.2005; 16:905-10.

• Other Product Names :

  LASS6 Antibody: CERS5, LASS6, Ceramide synthase 6, LAG1 longevity assurance homolog 6, CerS6

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  80478334

• Physical Properties :

  Liquid